Telomeres and aging:

How to keep your skin younger.

Each person is formatted through a unique genetic makeup. This molecular blueprint – your chromosomes- is capped at the end with telomeres. Telomeres prevent chromosomes from unraveling or deteriorating, and also protect chromosomes from fusing together, avoiding malfunctioning chromosomes. A telomere is commonly compared to the protective plastic tip on the end of your shoelace due to these properties. Every time a cell divides- which is vital for new skin, blood and bone tissue reproduction- the telomere protects the DNA from losing essential gene information, but the telomere becomes shorter after each division. When it becomes too short, the cell becomes dormant, dies or may retain generic damage that can eventually lead to mutations and cancer. Shortened telomeres have been associated with cardiovascular disease, cancer and diabetes. Longer telomeres are linked to overall healthy living and longevity.

As chromosomes lose their telomeres throughout time, this affects skin’s aging. As you age, your risk factors increase due to a weakened immune system and naturally decreased cell division. “Telomere triggers” that can limit telomere repair and create telomere erosion are found throughout daily activities. Oxidative stress and glycation play a role by damaging and inhibiting DNA, lipids and peptides within the body. UV exposure limits telomere repair and can also initiate telomere-shortening.

A common factor within these telomere triggers is inflammation. When the skin becomes irritated ar traumatized, it becomes inflamed. Too much inflammation can initiate an accelerated aging process leading to premature pigmentation, elastosis, and fine lines and wrinkles. These skin conditions can be addressed through exfoliation or peels.

Source “Skin Inc” April 2014

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